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Research and development
Organic synthesis laboratory equipment
We can perform experiments applying the scale-down concept for the assigned reactor in our facility, using the jacketed reactor and various shapes of impeller. There are cases where the shape of the impeller has influenced the results of the reaction, so we make sure to implement the scale-up reaction with this equipment. The Kilolab, which is installed by 20 L reactor equipped with three-blade retreat impeller, allows us to conduct the large amount of sample productions.
Reaction/technology
Based on our knowledge and experience in process development and commercialization as CDMO, we will identify the challenges for scale-up and propose the solutions and measures.
We perform experiments applying the scale-down concept using the reactor equipped with the impeller and jacket to assigned reactor in our facility and also simulation tools for optimizing reaction rate, flow diagram analysis, analysis of the heat of reactions, etc.
Substances(examples)
Water-reactive reagents: n-BuLi, sec-BuLi, 60% NaH, etc.
Fire Services Act Class 5 Dangerous Goods: Organic peroxides, NaN3, hydroxylamine hydrochloride, etc.
Gas cylinder: Hydrogen gas, carbon dioxide gas, argon, etc.
Others: Phosphorus pentasulfide, inorganic CN compounds, diborane, bromine, fluorinating agent, etc.
Equipment
Reactor
Jacket reactor (50 mL–9 L; glass) and pressurized reactor (10 mL–2 L; stainless steel, glass).
Anchor blade, Three-blade retreat impeller, Highly-efficient multifunctional mixing impeller, etc.
Synthesis equipment
Automatic/semi-automatic organic synthesis equipment, microflow reactor, and high-speed flash automatic purification system.
Filter(centrifuge)
Small centrifuge (φ = 100 mm; stainless steel).
Mills
Pin mill, cutter mill, hammer mill, and jet mill.
Analysis equipment
HPLC (32 devices; UV/PDA/RI/CAD), GC (12 devices; FID/TCD), KF (5 devices; coulometric titration/volumetric titration), LC/MS, High Resolution MS (Orbitrap Exploris), LC/MS/MS, GC/MS, ion chromatography, NMR, PAT (Process Analytical Technology) Equipment (React-IRTM, FBRM, PVM), DSC/TGA, small-scale reaction calorimeter, and optical/electron microscopy.
Equipment(Kilolab)
Reactor
Jacket reactor (20 L; glass)
Three-blade retreat impeller
Operating temperature: –65 to 180℃
UTT: Heat transfer medium (–80 to 220℃)
Filter(Pressurized filter)
10 L; Teflon lining
Rotary evaporator
10 L; glass
Distillation column
Wiped film evaporator, Oldershaw distillation column (10, 15, and 25 plates) and reboiler (15 L; glass)
