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Production technology
Organic synthesis technology
Based on our organic synthesis technology, we have manufactured and supplied over 50 APIs and intermediates. We supply high quality products with reasonable costs satisfying demands and expectations of our clients. We have performed the successful scale-up of reactions using difficult-to-handle chemical reagents such as pyrophoric organometallic compounds including butyl lithium and highly toxic substances such as sodium cyanide.
We provide optimal solutions for the smooth progression of our clients’ projects.
Super-low-temperature reaction
We can utilize this reaction from pilot to commercial scale.
［Pilot equipment］
Stainless Steel 316: 300 and 500L
Anchor blade with auxiliary blades
Jacket: –50 to 120℃
Coil: Liquid nitrogen –196℃
［Commercial equipment］
Stainless Steel 316L
and HC22 equivalent: 3–10m3
Fullzone blade, etc.
Jacket: –50 to 50℃
Coil: Liquid nitrogen –196℃
Biotechnology
Since our successful industrialization of the enzymatic asymmetric reduction of ketones, our company has used biotechnology in many different processes, such as the production of optically active alcohols. Based on appropriate enzyme selection, we are able to provide cost efficient processes for diverse products with high selectivity.
①Side chains of statins
We have established commercial process for high enantio pure CHE (ethyl (S)-4-chloro-3-hydroxybutyrate) with enzymatic method. This technology has advantages in the selectivity compared to organometallic catalysts.
②Statin APIs
Some statins have di-hydroxy side chain. We screened a lot of enzymes which can reduce corresponding di-keto bulky substrate and found desired enzyme with high enantio/diastereo selectivity.
③Unnatural amino acids
We have established technology for the production of (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hemisulfate（VCPA) by combining regioselective enzymatic hydrolysis and Curtius rearrangement reaction. Our company succeeded in ton scale production.
